인체 조골세포 MG-63 세포증식에 미치는 생약초 추출물의 효과
The effect of medicinal plants extracts on the cell growth in the MG-63 human osteoblast cell
이숙영, 장은숙, 진승찬, 박정강, 박상혁, 김수관,
소속 상세정보
이숙영 ( Lee Sook-Young ) - 조선대학교 구강생물학연구소
장은숙 ( Jang Eun-Sook ) - 조선대학교 구강생물학연구소
진승찬 ( Jin Seung-Chan ) - 조선대학교 치과대학 구강악안면외과학교실
박정강 ( Piao Zheng-Gang ) - 조선대학교 치과대학 구강악안면외과학교실
박상혁 ( Park Sang-Hyeok ) - 조선대학교 치과대학 구강악안면외과학교실
김수관 ( Kim Su-Gwan ) - 조선대학교 치과대학 구강악안면외과학교실
KMID : 0353320110350010041
Abstract
In the present study we investigated the proliferative effect of human osteoblast MG-63 cell treated with 8 spp. medicinal plant extracts to screen the active compounds. Plant extracts were prepared by ethanol extraction method from Carthamus tinctorius seeds, Rhynchosia volubilis seeds, Camellia japonica leaves, Acanthopanax senticosus root and wood, Eucommia ulmoides bark, Chaenomeles sinensis flesh, Sambucus sieboldiana stem, Achyranthes japonica whole plant. A osteoblast proliferation test was conducted by MTT assay on 24 wellplate. Among 8 extracts, R. volubilis seeds and C. japonica leaves showed relatively strong stimulatory activity on osteoblast proliferation at the concentration of 12.5-200 /mL. Also Chaenomeles sinensis flesh, Sambucus sieboldiana stem, Achyranthes japonica whole plant showed cell viability of above 80% at the concentration of 25 /mL. These results suggested that 3 extracts may have beneficial effects on alveolar bone health through the proliferation of osteoblast cells.
키워드
Camellia japonica; Carthamus tinctorius; Osteoblast; Proliferation; Rhynchosia volubilis
원문 및 링크아웃 정보
등재저널 정보